Technology and Products

JJP-12

JJP-12 is a water-soluble small molecule which produced from microorganism, and more specifically by a subisolate of the slime mold Lysobacter antibioticus.

JJP-12 demonstrates a strong anti-arthritic activity vs. type II
collagen-induced arthritis in mice comparable to Enbrel (Entracept), an established therapeutic compound. JJP-12 and Enbrel, however, have different mechanisms of action: Enbrel, inhibits the migration of the disease to uninvolved paws where inhibition (rather than reversal) occurred over time, while JJP-12 reduces the global arthritis score in all affected paws making it highly relevant for the treatment of established rheumatoid diseases.

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Micro CT and Bone Density Evaluation

Regions of marked bone erosions are clearly visible in the image from the control group
(6A), while animals treated with JJP-12 (6B) showed only minor erosive changes. There was
considerable preservation of structure and bone mineral density in mice treated with JJP-12, which is not shown in mice treated with Enbrel (6C).